Ariko ubushakashatsi bushya bw’abahanga bugaragaza ko uyu muti ushobora kuba ufite undi murimo ukomeye mu buvuzi: gufasha mu kugabanya ubushobozi bwa kanseri bwo gukwirakwira mu mubiri.
Ibi byatangajwe nyuma y’ubushakashatsi bwakozwe n’abashakashatsi bo muri Weizmann Institute of Science muri Israel, bagaragaje ko ikinyabutabire gikora muri Viagra, kizwi nka sildenafil, gishobora kubangamira uburyo uturemangingo twa kanseri dukoresha cholesterol kugira ngo twiyongere kandi dukwirakwire mu bindi bice by’umubiri.
Nubwo ibi byavumbuwe bishimishije, abahanga baracyaburira ko Viagra itari umuti wa kanseri kandi ko abarwayi batagomba kuyikoresha bagamije kuvura kanseri.
Ibyabonetse biri mu rwego rw’ubushakashatsi bukomeje gukorwa kugira ngo harebwe niba uyu muti ushobora kuzagira uruhare mu buvuzi bwa kanseri mu gihe kizaza.
Viagra yari izwiho iki mbere?
Viagra, izina rizwi cyane ry’umuti urimo sildenafil, yatangiye gukoreshwa cyane nyuma yo kwemezwa mu myaka ya za 1990 nk’umuti uvura ikibazo cyo kudakora neza kw’imyanya ndangagitsina y’abagabo.
Ubusanzwe sildenafil yari yarakorewe ubushakashatsi harebwa niba yafasha mu kuvura indwara z’umutima n’umuvuduko w’amaraso, ariko nyuma abahanga babona ko ifite ubushobozi bwo kongera amaraso ajya mu bice bimwe by’umubiri.
Kuva icyo gihe, Viagra yabaye umwe mu miti imenyerewe cyane ku isi, aho abantu benshi bayikoresha kubera icyo yashyiriweho mbere.
Ariko mu buvuzi, hari uburyo buzwi nka drug repurposing, aho abahanga basuzuma imiti isanzwe ikoreshwa bakareba niba ishobora kugira indi mirimo mu kuvura izindi ndwara.
Ni muri urwo rwego ubushakashatsi kuri sildenafil na kanseri bwatangiriye.
Ubushakashatsi bushya bwagaragaje iki?
Ubushakashatsi bwakozwe n’ikipe iyobowe na Prof. Ayelet Erez na Dr. Yarden Ariav bo muri Weizmann Institute of Science, bugaragaza ko sildenafil ishobora kugabanya ubushobozi bwa kanseri bwo gukora icyo abahanga bita metastasis.
Metastasis ni igihe uturemangingo twa kanseri tuva aho twatangiriye tukajya mu bindi bice by’umubiri, bigatuma indwara irushaho gukomera.
Abashakashatsi basanze sildenafil ishobora guhungabanya uburyo kanseri ikoresha cholesterol, ikintu gifasha uturemangingo kubaka ibice byatwo no gukora ibikorwa bitandukanye.
Mu buryo busanzwe, cholesterol ni ikintu gikenewe mu mubiri w’umuntu kugira ngo uturemangingo dukore neza. Ariko ku turemangingo twa kanseri, cholesterol ishobora gufasha mu kwiyongera, kwimuka no gufata ibindi bice by’umubiri.
Iyo uburyo bwo kubona cyangwa gukoresha cholesterol bubangamiwe, ubushobozi bwa kanseri bwo gukwirakwira bushobora kugabanuka.
Ni gute Viagra ishobora kubangamira kanseri?
Abashakashatsi basobanura ko sildenafil ihagarika ikinyabutabire kizwi nka PDE5. Iyo PDE5 ihagaritswe, umubiri wongera urugero rw’ikindi kinyabutabire kizwi nka cGMP.
Ubu bushakashatsi bwagaragaje ko cGMP ishobora kugira uruhare mu guhindura uburyo cholesterol itwarwa imbere mu turemangingo.
Ibyo bishobora gutuma cholesterol iguma ahantu mu turemangingo aho kanseri itayibona neza, bigatuma uturemangingo twa kanseri tugira ikibazo cyo gukomeza kwimuka no gukwirakwira.
Mu magambo yoroshye, abahanga bavuga ko sildenafil ishobora kuba nk’ikintu kimeze nka lisansi kanseri ikenera kugira ngo ikomeze gukwirakwira mu mubiri.
Ubushakashatsi bwakorewe he kandi hakoreshejwe iki?
Kugira ngo bagere kuri ibi bisubizo, abashakashatsi bakoresheje uburyo butandukanye burimo: kugeragereza ku turemangingo twa kanseri twakuwe ku bantu, kugeragereza ku nyamaswa zifashishwa mu bushakashatsi, no gusesengura amakuru y’ubuzima bw’abantu benshi bamaze imyaka myinshi bakurikiranwa.
Itsinda ry’abashakashatsi ryakoresheje kandi amakuru y’abarwayi bagera kuri miliyoni eshanu bo mu kigo cy’ubuzima cya Israel kizwi nka Clalit Health Services, harebwa isano iri hagati yo gukoresha sildenafil n’imyitwarire ya kanseri.
Iri sesengura ryagaragaje ko bamwe mu barwayi ba kanseri bari barakoresheje sildenafil bagaragaje imibereho myiza kurusha abandi, cyane cyane iyo sildenafil yahuriraga hamwe n’imiti igabanya cholesterol izwi nka statins.
Ariko abashakashatsi bashimangira ko ibi bitaragaragaza ko sildenafil ari yo yateye iryo hinduka, ahubwo ko hakenewe andi magerageza kugira ngo haboneke igisubizo gifatika.
Ese Viagra ishobora guhita ikoreshwa mu kuvura kanseri?
Oya. Nubwo ubushakashatsi bushya bwatanze icyizere, haracyari inzira ndende mbere y’uko sildenafil yemezwa nk’umuti ugabanya kanseri.
Abahanga bavuga ko hakenewe: amagerageza manini ku bantu bafite kanseri, kumenya ubwoko bwa kanseri bushobora kuvurwa muri ubu buryo, kumenya urugero rw’umuti rukwiye, no kumenya neza niba umutekano wawo ku barwayi ba kanseri wizewe.
Kugeza ubu, Viagra ikomeje gukoreshwa ku mpamvu zemewe mbere, kandi gukoresha imiti iyo ari yo yose bigomba gukorwa hakurikijwe inama z’abaganga.
Abashakashatsi bavuga ko ubu bushakashatsi bushobora gufasha mu gusobanukirwa neza uburyo kanseri ikura n’uko yakumirwa.
Kuva kera, abahanga bibandaga cyane ku guhinduka kwa ADN y’uturemangingo twa kanseri, ariko ubu ubushakashatsi bushya burimo kureba n’uruhare rw’imiterere y’umubiri w’umurwayi, imikorere y’umubiri n’imiti aba asanzwe akoresha.
Ibi bishobora gufasha mu gutegura ubuvuzi bwihariye bujyanye n’umurwayi aho gukoresha uburyo bumwe ku bantu bose.
Ubushakashatsi bushya kuri Viagra bwatangaje isi y’ubuvuzi kuko bwagaragaje ko umuti wari uzwi cyane ku rundi rwego ushobora kuzagira undi murimo mu kurwanya ikwirakwira rya kanseri.
Icyakora abahanga baracyasaba kwitonda, kuko ibi ntibivuze ko Viagra yavura kanseri, ahubwo ni ubushakashatsi bushobora gufungura inzira nshya mu gushaka uburyo bwo kugabanya metastasis.